Is it possible to sustain youth and to beimpenetrable?
NADH/NAD+ is avital co-enzyme couple that plays a significant role in energy production/consumption within the cells of living organisms.
It was published in Science by Professor David Sinclair(Harvard Medical School,2017) that NAD+ could underlie some effects of aging and propensity to age-related diseases. These include activating the body’s defenses against aging, deleting senescent cells, and reprogramming cells in vivo. Some researchers have found that NADH is beneficial for patients who are suffering from diabetes, Parkinson’s disease, Alzheimer’s disease, and depression.
In April 4 2020,it was reported in Biorxiv that COVID-19 infection strikingly depress NAD levels. Early preclinical data show that nutritional and pharmacological interventions to enhance NAD-based defenses may boost innate immunity.
Due to its importance, NADH detection has received much attention. A variety of analytical methods have been proposed for NADH sensing, including colorimetry, photo-electrochemistry, enzymatic assay, and high- performance liquid chromatography. Among these methods, electrochemical sensors are likely to offer a highly sensitive and in situ analytical approach for the detection of NADH. Due to their rapid response, straightforward operation, and cost effectiveness electrochemical detection method can be applied to explore the predictors of treatment effect in age-related disease or epidemic disease.
As the pursuit for new forms of clean energy continues, with a host of solar, wind and hydropower projects coming online.A new type of battery,bio-fuel cell, is attempted to use organic carbon to produce electricity. Some scienteist used urine to get electricity . It was called ‘Pee Power’. The first Pee Power urinal was installed on the Frenchay Campus at University of West England, in which the lighting within the toilet structure was powered by microbial fuel cells feeding off the urine.If you are want to use this technology to charge mobile phones even a car one day,don’t waste your urine anymore at that time.
According to American Bone Health Organization, adults need between 1,000 and 1,200 mg of calcium a day. If you don't get enough calcium from your diet, your body will leech what it needs from bone, which ultimately leads to thinning. Milk is rich in calcium, so many people choose it as Calcium supplements. In Ismail’s research , in half of the samples,the level of Pb and Cd was found to exceed the permissible limit (0.02 µg/g and 0.0026 µg/g) set by International Dairy Federation. The toxic impacts of heavy metals on human health include skeletal damages, renal failure, cell damages, osteoporosis, cancer of lungs and blood, hormonal disturbances, gastrointestinal problems and anemia. Milk is chemically very complex, with many different ingredients. So detectiong the level of heavy metal in milk is turned into an important task. Up to now many achievements in electrochemisty field have been reported an used for actual test,which is easy to use and cheaply.
To date, cancer is one of the leading causes of death in human beings. One of the major causes of cancer-related deaths is cancer metastasis, which is closely correlated with circulating tumor cells(CTCs). Detecting CTCs at low concentrations is beneficial for real time monitoring of cancer metastasis and therapies. Some researchers reported they used 5-milliliter samples of healthy blood with 10 small-cell-lung cancer cells and then ran the blood through their device. They were able to recover 93 percent of the cancer cells using the microfluidic device. Many new techniques, including colorimetric, electrochemical and fluorescent imaging, have been effectively exploited to isolate and enumerate CTCs. Among these techniques, the electrochemical sensing methods are very attractive by virtue of their unique features, including low cost, high sensitivity and facile operation.
According to the CNN news, South Korea is experiencing the largest virus epidemic outside of China.So it come up with an innovative form of detecting for the novel coronavirus . People can have a testing by the drive-through counters just like at McDonalds and Starbucks. But the results still come back after within days,too slow for front-line screening.So there is urgent need for better methods of mass screening to contain the spread of the virus.In electrochemical field ,Pinpoint Science Inc is now developing an electrical biosensor for mass screening of the novel Covid-19 coronavirus which is using nano sensors and aptamer.
Until now, the 2019-nCoV has cause thousands of deaths and severe economic losses in the world. Now PCR detect viral nucleic acids directly，but this method require complex procedures, expensive instruments and high skilled personnel. Consequently, developing a commercially available rapid test strip is necessary and urgent. According to the Xinhua News ,China's Nankai University has announced a breakthrough in developing a novel coronavirus rapid test kit that can identify infection among suspected patients with in 15 min. This test kit called Novel Coronavirus (2019-nCoV) IgM/IgG antibody detection kit. The Nankai test kit is expected to be used in epidemic prevention and control soon, the university said.