To date, cancer is one of the leading causes of death in human beings. One of the major causes of cancer-related deaths is cancer metastasis, which is closely correlated with circulating tumor cells(CTCs). Detecting CTCs at low concentrations is beneficial for real time monitoring of cancer metastasis and therapies. Some researchers reported they used 5-milliliter samples of healthy blood with 10 small-cell-lung cancer cells and then ran the blood through their device. They were able to recover 93 percent of the cancer cells using the microfluidic device. Many new techniques, including colorimetric, electrochemical and fluorescent imaging, have been effectively exploited to isolate and enumerate CTCs. Among these techniques, the electrochemical sensing methods are very attractive by virtue of their unique features, including low cost, high sensitivity and facile operation.



Reference

1. Diagnostic Detection of Human Lung Cancer-Associated Antigen Using a Gold Nanoparticle-Based Electrochemical Immunosensor

2. Highly sensitive biosensor based on graphene–poly (3-aminobenzoic acid) modified electrodes and porous-hollowed-silver-gold nanoparticle labelling for prostate cancer detection