時至今日,癌症已經成為威脅人類健康的頭號殺手之一。在癌症造成的死亡病例中,癌細胞的轉移占了絕大部分,而癌細胞的轉移又與從原發癌脫落的循環腫瘤細胞(CTCs)有著密切的關係。所以如果可以檢測血液中低濃度的循環腫瘤細胞對于及時發現癌症轉移以及評估癌症治療方案有著重大的幫助。有研究學者報道,他們在5mL的健康血液中加入十個小細胞肺癌細胞,通過他們設計的微流體裝置,可以檢測出93%的目標物。如今在循环肿瘤细胞的分离和检测中,諸如比色法,電化學法,螢光發光影像法都被廣泛時候用。在這些技術中,電化學感測技術由於其獨特的優點(低成本,高靈敏度,操作簡便)而倍加矚目。

To date, cancer is one of the leading causes of death in human beings. One of the major causes of cancer-related deaths is cancer metastasis, which is closely correlated with circulating tumor cells(CTCs). Detecting CTCs at low concentrations is beneficial for real time monitoring of cancer metastasis and therapies. Some researchers reported they used 5-milliliter samples of healthy blood with 10 small-cell-lung cancer cells and then ran the blood through their device. They were able to recover 93 percent of the cancer cells using the microfluidic device. Many new techniques, including colorimetric, electrochemical and fluorescent imaging, have been effectively exploited to isolate and enumerate CTCs. Among these techniques, the electrochemical sensing methods are very attractive by virtue of their unique features, including low cost, high sensitivity and facile operation.

Reference

1. Diagnostic Detection of Human Lung Cancer-Associated Antigen Using a Gold Nanoparticle-Based Electrochemical Immunosensor

2. Highly sensitive biosensor based on graphene–poly (3-aminobenzoic acid) modified electrodes and porous-hollowed-silver-gold nanoparticle labelling for prostate cancer detection